Irinotecan (CPT-11) is a semisynthetic analog of camptothecin, isolated from Camptotheca acuminata. It is a chemotherapy agent that causes S-phase-specific cell killing by poisoning topoisomerase I (Topo I) in the cell.\r\nIrinotecan reduces levels of Topo I
Irinotecan is a derivative of camptothecin, an antitumor alkaloid isolated from Camptotheca acuminata and an inhibitor of topoisomerase-I
Semisynthetic derivative of a plant alkaloid, camptothecin it is a Topoisomerase-I inhibitors.
Irinotecan significantly elevated the MN in the mouse peripheral blood erythrocytes
Irinotecan shows antitumor activity by inhibits DNA Topoisomerase-I enzyme.
Irinotecan is a prodrug that is converted to the active metabolite form 10-hydroxy-7-ethylcamptothecin (SN38).
Irinotecan (CPT-11, Camptosar), a semisynthetic, water-soluble derivative of the plant alkaloid camptothecin. Irinotecan is an important new tool in the treatment of cancer.
Irinotecan belongs to the class of topoisomerase I inhibitors, shown a broad spectrum of antitumor activity
Irinotecan is a water-soluble and potent derivatives of camptothecin. It is a pro-drug that possesses limited antitumor activity, but is converted by the enzyme carboxylesterase to a very active compound (SN-38) in vivo. SN-38 is reported to be anywhere f
\r\nIrinotecan or 7-Ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin is a promising water soluble camptothecin derivative. The anticancer activity of irinotecan, an inhibitor of type I- DNA topoisomerase was demonstrated not only in murine tu
Irinotecan is obtained by modifications of A and B rings of camptothecin. Modifications involve addition to the quinoline ring or the complete replacement of the quinoline ring with an alternative ring system. Shows topoisomerase I inhibitory activity. It
Irinotecan (CPT-11/Camptosar / 7-ethyl-10-(4-(1-piperidino)-1-piperidino) carbonyloxy-camptothecin) is a semisynthetic, water-soluble derivative of camptothecin. It inhibits topoisomerase-I by DNAtopoisomerase-I complex formation. Like camptothecin, both