Table of Contents

Filter by status

BRICS
Public

Tool Box

Print
Citation
Toxicity

Myelosuppression and DiarrheaMyelosuppression,Gastrointestinal & DiarrheaNausea, Diarrhea, Vomiting, Hematological toxicityNeutropeniak, Diarrhea, MyelosuppressionMyelosuppression, Gastrointestinal toxicity

Reference

Title of Journal : Current Science  Author : Padmanabha B.V.  C_Author : Chandrashekar M., Ramesha B. T., Hombe Gowda H. C., Rajesh P. Gunaga, Suhas S., Vasudeva R., Ganeshaiah K. N. and Uma Shaanker R.  Year : 2006  Volume No. : 90  Issue No. : 1  Page No. : 95-100  
Title of Journal : Drug Metabolism And Disposition.\r\nThe American Society For Pharmacology And Experimental Therapeutics  Author : Nobumitsu Hanioka  C_Author : Shogo Ozawa  Year : 2002  Volume No. : 30  Issue No. : 4  Page No. : 391-396  
Title of Journal : Plant Cell Rep  Author : Lorence A.  C_Author : Medina Bolivar F.  Year : 2004  Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : Annals of Oncology  Author : Xu Y.  C_Author : Villalona-Calero M.A.  Year : 2002  Volume No. : 13  Issue No. :   Page No. : 1841-1851  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : jnci.oxfordjournals.org  Author : Vicki Brower  C_Author :   Year : 2011  Volume No. :   Issue No. :   Page No. : 838-839  
Title of Journal : Clinical Cancer Research  Author : Rocio Garcia-Carbonero  C_Author : Jeffrey Supko G.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 641-661  
Title of Journal : The Journal Of Pharmacology And Experimental Therapeutics  Author : Xiao Yan Chu  C_Author : Yukio Kato  Year :   Volume No. : 281  Issue No. : 1  Page No. : 304-314  
Title of Journal : Drug Metabolism And Disposition  Author : Takashi Nozawa  C_Author : Hironobu Minami  Year : 2005  Volume No. : 33  Issue No. : 3  Page No. : 434-439  
Title of Journal : Molecular Pharmacology  Author : Tracy Kim E.  C_Author : Shin Young Park  Year : 2004  Volume No. : 66  Issue No. : 2  Page No. : 285-292  
Title of Journal : The Oncologist  Author : Reginald Ewesuedo B.  C_Author : Mark Ratain J.  Year : 1997  Volume No. : 2  Issue No. :   Page No. : 359-364  
Title of Journal : Clinical Cancer Research  Author : Panayotis Pantazis  C_Author :   Year : 1995  Volume No. : 1  Issue No. :   Page No. : 1235-1244  
Title of Journal : BMC Plant Biology  Author : Alessio Valletta  C_Author : Livio Trainotti  Year : 2010  Volume No. : 10  Issue No. : 69  Page No. : 1-10  
Title of Journal : Biotechnol. Bioprocess Engg  Author : Sung Hye kim  C_Author : Byung Ki Hur  Year : 1999  Volume No. : 4  Issue No. :   Page No. : 277-280  
Title of Journal : Journal of Applied Pharmaceutical Science  Author : Xiaoning Ni  C_Author : Shiqiu Wen  Year : 2011  Volume No. : 1  Issue No. : 8  Page No. : 85-88  
Title of Journal : Records of Natural Products  Author : Ajay Namdeo G.  C_Author : Ajay Sharma  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 64-71  
Title of Journal : Global Journal of Pharmacology  Author : Soriful Islam M.  C_Author : Mauluda Akhtar Most.  Year : 2009  Volume No. : 3  Issue No. : 2  Page No. : 99-106  
Title of Journal : Environmental and Molecular Mutagenesis  Author : Sabry Attia M.  C_Author : Abdul Aziz Aleisa M.  Year : 2009  Volume No. :   Issue No. :   Page No. : 1-7  
Title of Journal : Clinical Cancer Research  Author : Min Huang  C_Author : Heyong Gao  Year : 2007  Volume No. : 13  Issue No. : 4  Page No. : 1298-1307  
Title of Journal : Thesis- Dept. Medical oncology, rotterdam cancer institute (daniel den hoed Kliniek) and university hospital rotterdam  Author : Comelis johannes hendrikus gerrits  C_Author :   Year : 1997  Volume No. :   Issue No. :   Page No. :   
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  
Title of Journal : In Vivo  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2005  Volume No. : 19  Issue No. :   Page No. : 283-292  
Title of Journal : The Oncologist  Author : Leonard Saltz B.  C_Author :   Year : 1997  Volume No. : 2  Issue No. :   Page No. : 402-409  
Title of Journal : Annals of Oncology  Author : Mross K.  C_Author : Richly H.  Year : 2004  Volume No. : 15  Issue No. :   Page No. : 1284-1294  
Title of Journal : Clinical Cancer Research  Author : Francis Giles J.  C_Author : Jorge Cortes E.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 2134-2141  
Title of Journal : Clinical Cancer Research  Author : Ron Mathijssen H. J.  C_Author : Robbert van Alphen J.  Year : 2001  Volume No. : 7  Issue No. :   Page No. :   
Title of Journal : Pharmaceutical Research  Author : Hatefi A.  C_Author : Amsden B.  Year : 2002  Volume No. : 19  Issue No. : 10  Page No. : 1389-1399  
Title of Journal : Japanese Journal of Cancer Research  Author : Yasutsuna Sasaki  C_Author : Hideo Hakusui  Year : 1995  Volume No. : 86  Issue No. :   Page No. : 101-110  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Brazilian Journal of Medical and Biological Research  Author : Grivicich  C_Author : Mans D.R.A.  Year : 2001  Volume No. : 34  Issue No. :   Page No. : 1087-1103  
Title of Journal : Journal of Pharmacy Research  Author : Pankaj Kumar Jangra  C_Author : Pramod Kumar Sharma  Year : 2010  Volume No. : 3  Issue No. : 12  Page No. : 3093-3096  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
comment on or rate this article

Explanation

Irinotecan (CPT-11) is a semisynthetic analog of camptothecin, isolated from Camptotheca acuminata. It is a chemotherapy agent that causes S-phase-specific cell killing by poisoning topoisomerase I (Topo I) in the cell.rnIrinotecan reduces levels of Topo IIrinotecan is a derivative of camptothecin, an antitumor alkaloid isolated from Camptotheca acuminata and an inhibitor of topoisomerase-ISemisynthetic derivative of a plant alkaloid, camptothecin it is a Topoisomerase-I inhibitors.Irinotecan significantly elevated the MN in the mouse peripheral blood erythrocytesIrinotecan shows antitumor activity by inhibits DNA Topoisomerase-I enzyme.Irinotecan is a prodrug that is converted to the active metabolite form 10-hydroxy-7-ethylcamptothecin (SN38).Irinotecan (CPT-11, Camptosar), a semisynthetic, water-soluble derivative of the plant alkaloid camptothecin. Irinotecan is an important new tool in the treatment of cancer.Irinotecan belongs to the class of topoisomerase I inhibitors, shown a broad spectrum of antitumor activityIrinotecan is a water-soluble and potent derivatives of camptothecin. It is a pro-drug that possesses limited antitumor activity, but is converted by the enzyme carboxylesterase to a very active compound (SN-38) in vivo. SN-38 is reported to be anywhere frnIrinotecan or 7-Ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin is a promising water soluble camptothecin derivative. The anticancer activity of irinotecan, an inhibitor of type I- DNA topoisomerase was demonstrated not only in murine tuIrinotecan is obtained by modifications of A and B rings of camptothecin. Modifications involve addition to the quinoline ring or the complete replacement of the quinoline ring with an alternative ring system. Shows topoisomerase I inhibitory activity. ItIrinotecan (CPT-11/Camptosar / 7-ethyl-10-(4-(1-piperidino)-1-piperidino) carbonyloxy-camptothecin) is a semisynthetic, water-soluble derivative of camptothecin. It inhibits topoisomerase-I by DNAtopoisomerase-I complex formation. Like camptothecin, both

Reference

Title of Journal : Current Science  Author : Padmanabha B.V.  C_Author : Chandrashekar M., Ramesha B. T., Hombe Gowda H. C., Rajesh P. Gunaga, Suhas S., Vasudeva R., Ganeshaiah K. N. and Uma Shaanker R.  Year : 2006  Volume No. : 90  Issue No. : 1  Page No. : 95-100  
Title of Journal : Drug Metabolism And Disposition.\r\nThe American Society For Pharmacology And Experimental Therapeutics  Author : Nobumitsu Hanioka  C_Author : Shogo Ozawa  Year : 2002  Volume No. : 30  Issue No. : 4  Page No. : 391-396  
Title of Journal : Plant Cell Rep  Author : Lorence A.  C_Author : Medina Bolivar F.  Year : 2004  Volume No. : 22  Issue No. :   Page No. : 437-441  
Title of Journal : Annals of Oncology  Author : Xu Y.  C_Author : Villalona-Calero M.A.  Year : 2002  Volume No. : 13  Issue No. :   Page No. : 1841-1851  
Title of Journal : Bangladesh J Pharmacol  Author : Mohammad Shoeb  C_Author :   Year : 2006  Volume No. : 1  Issue No. :   Page No. : 35-41  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : jnci.oxfordjournals.org  Author : Vicki Brower  C_Author :   Year : 2011  Volume No. :   Issue No. :   Page No. : 838-839  
Title of Journal : Clinical Cancer Research  Author : Rocio Garcia-Carbonero  C_Author : Jeffrey Supko G.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 641-661  
Title of Journal : The Journal Of Pharmacology And Experimental Therapeutics  Author : Xiao Yan Chu  C_Author : Yukio Kato  Year :   Volume No. : 281  Issue No. : 1  Page No. : 304-314  
Title of Journal : Drug Metabolism And Disposition  Author : Takashi Nozawa  C_Author : Hironobu Minami  Year : 2005  Volume No. : 33  Issue No. : 3  Page No. : 434-439  
Title of Journal : Molecular Pharmacology  Author : Tracy Kim E.  C_Author : Shin Young Park  Year : 2004  Volume No. : 66  Issue No. : 2  Page No. : 285-292  
Title of Journal : The Oncologist  Author : Reginald Ewesuedo B.  C_Author : Mark Ratain J.  Year : 1997  Volume No. : 2  Issue No. :   Page No. : 359-364  
Title of Journal : Clinical Cancer Research  Author : Panayotis Pantazis  C_Author :   Year : 1995  Volume No. : 1  Issue No. :   Page No. : 1235-1244  
Title of Journal : BMC Plant Biology  Author : Alessio Valletta  C_Author : Livio Trainotti  Year : 2010  Volume No. : 10  Issue No. : 69  Page No. : 1-10  
Title of Journal : Biotechnol. Bioprocess Engg  Author : Sung Hye kim  C_Author : Byung Ki Hur  Year : 1999  Volume No. : 4  Issue No. :   Page No. : 277-280  
Title of Journal : Journal of Applied Pharmaceutical Science  Author : Xiaoning Ni  C_Author : Shiqiu Wen  Year : 2011  Volume No. : 1  Issue No. : 8  Page No. : 85-88  
Title of Journal : Records of Natural Products  Author : Ajay Namdeo G.  C_Author : Ajay Sharma  Year : 2010  Volume No. : 4  Issue No. : 1  Page No. : 64-71  
Title of Journal : Global Journal of Pharmacology  Author : Soriful Islam M.  C_Author : Mauluda Akhtar Most.  Year : 2009  Volume No. : 3  Issue No. : 2  Page No. : 99-106  
Title of Journal : Environmental and Molecular Mutagenesis  Author : Sabry Attia M.  C_Author : Abdul Aziz Aleisa M.  Year : 2009  Volume No. :   Issue No. :   Page No. : 1-7  
Title of Journal : Clinical Cancer Research  Author : Min Huang  C_Author : Heyong Gao  Year : 2007  Volume No. : 13  Issue No. : 4  Page No. : 1298-1307  
Title of Journal : Thesis- Dept. Medical oncology, rotterdam cancer institute (daniel den hoed Kliniek) and university hospital rotterdam  Author : Comelis johannes hendrikus gerrits  C_Author :   Year : 1997  Volume No. :   Issue No. :   Page No. :   
Title of Journal : British Journal of Pharmacology  Author : Tsai T.H.  C_Author : Lee C.H.  Year : 2001  Volume No. : 134  Issue No. :   Page No. : 1245-1252  
Title of Journal : In Vivo  Author : Kathleen Legarza  C_Author : Li Xi Yang  Year : 2005  Volume No. : 19  Issue No. :   Page No. : 283-292  
Title of Journal : The Oncologist  Author : Leonard Saltz B.  C_Author :   Year : 1997  Volume No. : 2  Issue No. :   Page No. : 402-409  
Title of Journal : Annals of Oncology  Author : Mross K.  C_Author : Richly H.  Year : 2004  Volume No. : 15  Issue No. :   Page No. : 1284-1294  
Title of Journal : Clinical Cancer Research  Author : Francis Giles J.  C_Author : Jorge Cortes E.  Year : 2002  Volume No. : 8  Issue No. :   Page No. : 2134-2141  
Title of Journal : Clinical Cancer Research  Author : Ron Mathijssen H. J.  C_Author : Robbert van Alphen J.  Year : 2001  Volume No. : 7  Issue No. :   Page No. :   
Title of Journal : Pharmaceutical Research  Author : Hatefi A.  C_Author : Amsden B.  Year : 2002  Volume No. : 19  Issue No. : 10  Page No. : 1389-1399  
Title of Journal : Japanese Journal of Cancer Research  Author : Yasutsuna Sasaki  C_Author : Hideo Hakusui  Year : 1995  Volume No. : 86  Issue No. :   Page No. : 101-110  
Title of Journal : Bioorganic & Medicinal Chemistry  Author : Vandana Srivastava  C_Author : Arvind Singh Negi  Year : 2005  Volume No. : 13  Issue No. :   Page No. : 5892-5908  
Title of Journal : Brazilian Journal of Medical and Biological Research  Author : Grivicich  C_Author : Mans D.R.A.  Year : 2001  Volume No. : 34  Issue No. :   Page No. : 1087-1103  
Title of Journal : Journal of Pharmacy Research  Author : Pankaj Kumar Jangra  C_Author : Pramod Kumar Sharma  Year : 2010  Volume No. : 3  Issue No. : 12  Page No. : 3093-3096  

UAS,Bengaluru Language : English
Article rating from 0 people star ratingstar ratingstar ratingstar ratingstar rating Submission Date :2012-10-01
comment on or rate this article

Activity

Antitumor
Anticancer
Colorectal Cancer
Lung Cancer
Ovarian cancer

Funded by :
  BRICS :  
FAQ | Policy | Site Map | Feedback | Contact
© 2012 All Rights Reserved by IBIN Powered by Caritor Solutions
Best viewed in 1024x768 or higher screen mode on Internet Explorer v9.0 or higher, Mozilla v12.0 or higher, Google Chorme.